Effect on growth parameters of bone marrow transplantcation with a chemotherapy-only conditioning regimen

Transplantation Proceedings

Volume 8 - Number

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Introduction. The increasing use of bone marrow transplantation (BMT) has increased survival among a growing number of children and young adults afflicted by malignant and nonmalignant hematologic disorders. Accordingly, quality of life has emerged as an important issue. Because they are a concern in this group, we assessed growth and development, following chemotherapy-only conditioning regimens. Materials and Methods. Twelve prepubertal children (8 boys, GIP, and 4 gills, B(1)P(1)) with a mean age of 6 2 years (age range: 3.5 to 10 years) before and at 3, 6, 9, and 12 months post-BMT. Results. Growth velocity at 1 year posttransplant was 10.0+/-3.5 cm/y. One year post-BMT, the statistical deviation saturation for growth velocity was 4.31+/-4.2. Height standard deviation score was -1.4+/-1.2 before and -0.5+/-1.3 1 year post-BMT (P<.004). The average weight of our subjects was 20+/-6 kg before and 26+/-9.5 kg 1 year post-BMT. Discussion. BMT with a chemotherapy-only conditioning regimen not only does not disturb growth in children; it is actually associated with a relative growth spurt afterward.