Early pregnancy blood lead levels and the risk of premature rupture of the membranes

Reproductive Toxicology

Volume 3 - Number

Article Type: ---- Unspecified ----

To clarify the effects of lead on fetal premature rupture of the membranes (PROM), blood lead concentrations were measured using inductively coupled plasma-mass spectrometry in 332 women, aged 16-35 years, during their early pregnancy period (8-12 weeks). Blood lead concentrations were significantly higher in the 36 PROM deliveries than in the 296 non-PROM deliveries (mean +/- SD, 4.61 +/- 2.37 and 3.69 +/- 1.85 mu g/dl, respectively; p < 0.05). The logistic regression analysis revealed that a 1-unit increase in the logarithm of the blood lead level led to a several-fold increase in the risk of PROM (unit risk = 17.98, 95% CI 1.6-198.6). Thus, it is suggested that lead can increase the risk of PROM in pregnant women with mean blood lead less than 5 mu g/dl. (C) 2010 Elsevier Inc. All rights reserved.