Determination of Anti Colon Cancer Drug, Irinotecan by Fast Fourier Transforms Continuous Cyclic Voltammetry
In this work a novel method for the determination of irinotecan, an anti colon cancer drug, in flow-injection systems has been developed. The fast Fourier transform continuous cyclic voltammetry (FFTCV) at gold microelectrode in flowing solution system was used for determination of irinotecan in its pharmaceutical formulations. The developed technique is very simple, precise, accurate, time saving and economical, compared to all of the previously reported methods. The effects of various parameters on the sensitivity of the method were investigated. The best performance was obtained with the pH value of 2, scan rate value of 65 V/s, accumulation potential of 50 mV and accumulation time of 0.55 s. The proposed method has some advantages over other reported methods. The method was linear over the concentration range of 1850-53000 pg/ml (r=0.9933) with a limit of detection and quantitation 35.5 and 200 pg/ml, respectively.