Concordance between clinical and histopathologic diagnosis in recipient corneas

Letters in Drug Design & Discovery

Volume 6 - Number

Article Type: ---- Unspecified ----
Abstract:

PURPOSE. To specify a concordance rate between the preoperative clinical and the postoperative histopathologic diagnosis in recipient corneas referred to the pathology department of Central Eye Bank of Iran. METHODS. Concordance and discrepancy between the preoperative clinical and postoperative histopathologic diagnosis of recipient corneal buttons were evaluated. RESULTS. Overall, 340 corneal specimens were evaluated. The total concordance rate between the clinical and histopathologic diagnoses was 97.5%. The concordance rate in keratoconus, nonspecific scar and opacity, mustard gas keratopathy, combined keratoconus and dystrophy, postkeratorefractive keratectasia, and chemical burns was 100%. Discordant cases were observed in acquired corneal endothelial decompensation, corneal dystrophies, infectious keratitis, and miscellaneous causes, with the rate of 6.0%, 4.1%, 2.8%, and 16.6%, respectively. CONCLUSIONS. Our series demonstrated a significantly high concordance between the preoperative clinical and the postoperative histopathologic diagnosis in recipient corneas with different types of corneal disorders.