Argyrophilic proteins of nucleolar organizer regions (AgNORs) in salivary gland mucoepidermoid carcinoma and its relation to histological grade

Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology

Volume 6 - Number

Article Type: ---- Unspecified ----

Objective. The aim of this study was to assess the cellular proliferation rate of major and minor salivary gland mucoepidermoid carcinomas (MECs) by quantitative analysis of AgNOR and to determine its relation to histopathologic grading. Study design. Thirty-five cases of major and minor salivary gland MECs, were retrieved and graded according to the AFIP grading schema. The mean AgNOR count was calculated for all cases. Results. Mean AgNOR counts were 0.64 +/- 0.15 in low-, 1.04 +/- 0.21 in intermediate-, and 1.42 +/- 0.23 in high-grade MECs. A significant difference was observed in the mean AgNOR counts among the 3 groups (P < .001). Conclusion. It can be suggested that the AgNOR technique can be applied on routine histological samples to assess the growth potential of MECs. However, its prognostic value should be validated with clinical studies and survival analyses.