Evaluation of tissue expression of matrix metalloproteinase 2, 9 and tissue inhibitor of matrix metalloproteinase 1 and 2 in gastric adenocarcinoma patients and their correlation with patient survival, prognosis and microvascular density(MVD)

گوارش، مجله انجمن متخصصين گوارش و كبد ايران

دوره 19 - شماره Suppl.1

Article Type: ---- Unspecified ----
Abstract:

Introduction: Gastric cancer is the most common GI cancer and the leading cause cancer related mortality in Iran. Proteolysis of the normal tissue proteins around the neoplasic tissue is one of the most important procedures causes spreading and metastasis of the tumors. Matrix metalloproteinases (MMPs) are the main endopeptidases have an important role in these procedures. In the other hand, a group of proteins, Tissue inhibitors of metalloproteinases (TIMPs), are known. And imbalance of MMPs and TIMPs plays a critical role in pathologic procedures of cancers such as spreading and metastasis. We sough to assess the tissue expression of matrix metalloproteinase 2, 9 and tissue inhibitor of matrix metalloproteinase 1 and 2 in gastric adenocarcinoma patients and their correlation with patient survival, prognosis and microvascular density(MVD). Method: Eighty-two patients with gastric adenocarcinoma who underwent gastrectomy surgery in Omid hospital of Mashhad were enrolled. Demographic and clinical was reviewed. Histological grade and stage of tumor were determined by single expert GI pathologist using TNM staging system. Tissue expression of MMP2, MMP9, TIMP-1 and TIMP-2 in the tumoral tissue was investigated by immunohistochemistry technique. Data were analyzed using SPSS software. Results: Fifty-eight patients (70. 7%) were male with the mean age of 62. 2 years (SD 10. 5 years) No association was found between tissue expression of matrix metalloproteinase 2, 9 and tissue inhibitor of matrix metalloproteinase 1 and 2 and histological grade and tumor stage in patients with gastric adenocarcinoma. Conclusion: Tissue expression of matrix metalloproteinase 2, 9 and tissue inhibitor of matrix metalloproteinase 1 and 2 are not associated with histological grade and tumor stage in patients with gastric adenocarcinoma. Further studies with greater sample size are suggested.

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