Serum and Peritoneal Fluid Level of Vascular Endothelial Growth Factor in Endometriosis
Background: Endometriosis is known as one of the most common disease in women of reproductive age. Due to importance role of vascular endothelial growth factor (VEGF) in neo-vascularization for the implantation of endometrial cell and different reported results for VEGF level in the serum and peritoneal fluid (PF) in endometriosis patients, this study was designed to determine the serum and PF levels of VEGF in endometriosis patients, and to compare it with normal subjects. Materials and Methods: Women who were subjected to laparoscopy for the evaluation of infertility or pelvic pain were allocated into two groups; women with (group I, n= 90) and without (group II, n=89) endometriosis. The PF from pelvis and venous blood samples were obtained. The VEGF concentration of the serum and PF were measured using enzyme immunoassay kit and were compared using t-Student test. Results: The level of VEGF level in serum was significantly less than in PF in both groups (p=0.00). However endometriosis patients had a higher level of VEGF in peritoneal fluid significantly when compared with nonendometriosis patients (p=0.043). Conclusion: Angiogenic activity is increased by the elevated level of VEGF in the PF of endometriosis patients. This elevated level of VEGF also promotes neovascularization within the peritoneal environment.This disease is associated with only pelvic inflammation, and is not associated change in the level of circulating VEGF.