Cancer Vaccines Are Limited by Adaptive Changes within the Tumor Microenvironment
Cancer vaccines are emerging as useful tools for suppressing tumor growth. However, in spite of the robust protective effects displayed by cancer vaccines in numerous settings, these agents have proven to be of
limited value in tumor-bearing hosts. Using a murine model with a prototypic cancer vaccine, we have determined that tumors adapt rapidly to immune attack by creating an immune suppressive environment that limits the effectiveness of the vaccine. The molecular pathways involved in this adaptive response and strategies to overcome the immune suppression will be discussed.